2-Methoxyethylamine → HCID 131725526, compound

HRID 1745180Notes

Reaction equation

HRID 1745180 reaction equation
[CH2:1]([O:4][N:5]=[C:6]1[CH2:10][N:9]([C:11]([O:13]C(C)(C)C)=O)[C@H:8]([C:18]([OH:20])=O)[CH2:7]1)[CH:2]=[CH2:3].[N:21]([C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([CH3:30])[CH:25]=1)=C=O.[CH3:31][O:32][CH2:33][CH2:34][NH2:35]>>[CH2:1]([O:4][N:5]=[C:6]1[CH2:10][N:9]([C:11]([NH:21][C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([CH3:30])[CH:25]=2)=[O:13])[C@H:8]([C:18]([NH:35][CH2:34][CH2:33][O:32][CH3:31])=[O:20])[CH2:7]1)[CH:2]=[CH2:3]

Participants

4

Reactant 3

HCID 80182-MethoxyethylamineHCID 69303m-Tolyl isocyanateHCID 58714562(2S,4EZ)-4-[(allyloxy)imino)-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid

Product 1

HCID 131725526HCID 131725526, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-4-[(allyloxy)-imino]-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, 1-isocyanato-3-methylben-zene, and 2-methoxyethylamine the title compound was obtained in 85% purity by LC/MS. MS(ESI+): m/z=375.2.

Sources & evidence

ORD record
ord-2a4bf0c2f0584366832662dd11210879
Source dataset
uspto-grants-2006_03
Patent number
US07018988B2

Reaction notes

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