Tert-Butylamine → HCID 69251249, compound

HRID 1745204Notes

Reaction equation

HRID 1745204 reaction equation
C(O[C:6]([N:8]1[CH2:12][C:11](=[CH:13][Cl:14])[CH2:10][C@H:9]1[C:15]([OH:17])=O)=[O:7])(C)(C)C.[C:18]1([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH:23]=[CH:22][C:21](C(Cl)=O)=[CH:20][CH:19]=1.[C:33]([NH2:37])([CH3:36])([CH3:35])[CH3:34]>>[C:27]1([C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH:28]=[CH:29][C:30]([C:6]([N:8]2[CH2:12][C:11](=[CH:13][Cl:14])[CH2:10][C@H:9]2[C:15]([NH:37][C:33]([CH3:36])([CH3:35])[CH3:34])=[O:17])=[O:7])=[CH:31][CH:32]=1

Participants

4

Reactant 3

HCID 6385Tert-ButylamineHCID 841514-Phenylbenzoyl chlorideHCID 69251379HCID 69251379, compound

Product 1

HCID 69251249HCID 69251249, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(chloromethylene)-2-pyrrolidinecarboxylic acid, [1,1′-biphenyl]-4-carbo-nyl chloride, and tert-butylamine the title compound was obtained in 80% purity by LC/MS. MS(ESI+): m/z=397.6.

Sources & evidence

ORD record
ord-d80cd3edd7b74bd180418ac454f8fff9
Source dataset
uspto-grants-2006_03
Patent number
US07018988B2

Reaction notes

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