Benzo-1,3-dioxole-5-methylamine → HCID 69250312, compound

HRID 1745212Notes

Reaction equation

HRID 1745212 reaction equation
C(O[C:6]([N:8]1[CH2:12][C:11](=[CH:13][Cl:14])[CH2:10][C@H:9]1[C:15]([OH:17])=O)=[O:7])(C)(C)C.[C:18]1([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH:23]=[CH:22][C:21](C(Cl)=O)=[CH:20][CH:19]=1.[O:33]1[C:37]2[CH:38]=[CH:39][C:40]([CH2:42][NH2:43])=[CH:41][C:36]=2[O:35][CH2:34]1>>[O:33]1[C:37]2[CH:38]=[CH:39][C:40]([CH2:42][NH:43][C:15]([C@@H:9]3[CH2:10][C:11](=[CH:13][Cl:14])[CH2:12][N:8]3[C:6]([C:30]3[CH:29]=[CH:28][C:27]([C:18]4[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=4)=[CH:32][CH:31]=3)=[O:7])=[O:17])=[CH:41][C:36]=2[O:35][CH2:34]1

Participants

4

Reactant 3

HCID 75799Benzo-1,3-dioxole-5-methylamineHCID 841514-Phenylbenzoyl chlorideHCID 69251379HCID 69251379, compound

Product 1

HCID 69250312HCID 69250312, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(chloromethylene)-2-pyrrolidinecarboxylic acid, [1,1′-biphenyl]-4-carbo-nyl chloride, and 1,3-benzodioxol-5-ylmethylamine the title compound was obtained in 63% purity by LC/MS. MS(ESI+): m/z=475.6.

Sources & evidence

ORD record
ord-5f1406d67cbf4fa484b55f6a7185e685
Source dataset
uspto-grants-2006_03
Patent number
US07018988B2

Reaction notes

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