Furfurylamine → HCID 69253011, compound

HRID 1745218Notes

Reaction equation

HRID 1745218 reaction equation
C(O[C:6]([N:8]1[CH2:12][C:11](=[CH:13][Cl:14])[CH2:10][C@H:9]1[C:15]([OH:17])=O)=[O:7])(C)(C)C.C(Cl)(=O)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.[O:27]1[CH:31]=[CH:30][CH:29]=[C:28]1[CH2:32][NH2:33]>>[C:6]([N:8]1[CH2:12][C:11](=[CH:13][Cl:14])[CH2:10][C@H:9]1[C:15]([NH:33][CH2:32][C:28]1[O:27][CH:31]=[CH:30][CH:29]=1)=[O:17])(=[O:7])[C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

Participants

4

Reactant 3

HCID 3438FurfurylamineHCID 7412Benzoyl chlorideHCID 69251379HCID 69251379, compound

Product 1

HCID 69253011HCID 69253011, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(chloromethylene)-2-pyrrolidinecarboxylic acid, benzoyl chloride, and 2-furylmethylamine the title compound was obtained in 73% purity by LC/MS. MS(ESI+): m/z=345.6.

Sources & evidence

ORD record
ord-507302c8ae7c48af9dd9ab1488170b49
Source dataset
uspto-grants-2006_03
Patent number
US07018988B2

Reaction notes

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