Benzoyl chloride → HCID 69247693, compound

HRID 1745227Notes

Reaction equation

HRID 1745227 reaction equation
C(O[C:6]([N:8]1[CH2:12][C:11](=[CH:13][Cl:14])[CH2:10][C@H:9]1[C:15]([OH:17])=O)=[O:7])(C)(C)C.C(Cl)(=O)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.[CH2:27]([NH:34][CH3:35])[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1>>[C:6]([N:8]1[CH2:12][C:11](=[CH:13][Cl:14])[CH2:10][C@H:9]1[C:15]([N:34]([CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)[CH3:35])=[O:17])(=[O:7])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

4

Reactant 3

HCID 7412Benzoyl chlorideHCID 7669N-MethylbenzylamineHCID 69251379HCID 69251379, compound

Product 1

HCID 69247693HCID 69247693, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(chloromethylene)-2-pyrrolidinecarboxylic acid, benzoyl chloride, and N-benzyl-N-methylamine the title compound was obtained in 62% purity by LC/MS. MS(ESI+): m/z=369.4.

Sources & evidence

ORD record
ord-73d51cdca74843c799434535e11d5c96
Source dataset
uspto-grants-2006_03
Patent number
US07018988B2

Reaction notes

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