Phenoxyacetyl chloride → HCID 131725562, compound

HRID 1745228Notes

Reaction equation

HRID 1745228 reaction equation
C(O[C:6]([N:8]1[CH2:12][C:11](=[N:13][O:14][CH2:15][CH3:16])[CH2:10][C@H:9]1[C:17]([OH:19])=O)=[O:7])(C)(C)C.[O:20]([CH2:27]C(Cl)=O)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.[CH:31]([N:44]1[CH2:49][CH2:48][NH:47][CH2:46][CH2:45]1)([C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1)[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1>>[CH2:15]([O:14][N:13]=[C:11]1[CH2:10][C@@H:9]([C:17]([N:47]2[CH2:48][CH2:49][N:44]([CH:31]([C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)[C:38]3[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=3)[CH2:45][CH2:46]2)=[O:19])[N:8]([C:6](=[O:7])[CH2:27][O:20][C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH2:12]1)[CH3:16]

Participants

4

Reactant 3

HCID 69703Phenoxyacetyl chlorideHCID 70048BenzhydrylpiperazineHCID 58714540(2S,4EZ)-1-(tertbutoxycarbonyl)-4-(ethoxyirnino)-2-pyrrolidinecarboxylic acid

Product 1

HCID 131725562HCID 131725562, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(ethoxyimino)-2-pyrrolidinecarboxylic acid, phenoxyacetyl chloride, and 1-benzhydrylpiperazine the title compound was obtained in 67% purity by LC/MS. MS(ESI+): m/z=541.2.

Sources & evidence

ORD record
ord-ad11d924d20947fbab1d1c234641d1c4
Source dataset
uspto-grants-2006_03
Patent number
US07018988B2

Reaction notes

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