2-Methoxyethylamine → HCID 86621299, compound

HRID 1745230Notes

Reaction equation

HRID 1745230 reaction equation
C(O[C:6]([N:8]1[CH2:15][C:14](=[CH2:16])[CH2:13][C@H:9]1[C:10]([OH:12])=O)=[O:7])(C)(C)C.[N:17]([C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([CH3:26])[CH:21]=1)=C=O.[CH3:27][O:28][CH2:29][CH2:30][NH2:31]>>[CH3:27][O:28][CH2:29][CH2:30][NH:31][C:10]([CH:9]1[CH2:13][C:14](=[CH2:16])[CH2:15][N:8]1[C:6]([NH:17][C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([CH3:26])[CH:21]=1)=[O:7])=[O:12]

Participants

4

Reactant 3

HCID 80182-MethoxyethylamineHCID 69303m-Tolyl isocyanateHCID 21727417(2S)-1-((tert-butoxy)carbonyl)-4-methylidenepyrrolidine-2-carboxylic acid

Product 1

HCID 86621299HCID 86621299, compound

Procedure

Following the general method as outlined in Example 22, starting from 1-(tert-butoxycarbonyl)-4-methyleneproline, 1-isocyanato-3-methylbenzene, and 2-methoxyethylamine the title compound was obtained in 85% purity by LC/MS. MS(ESI+): m/z=318.0.

Sources & evidence

ORD record
ord-7f5fd3a2e5d94039ba9d42d311e2581d
Source dataset
uspto-grants-2006_03
Patent number
US07018988B2

Reaction notes

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