1-Naphthalenemethanamine → HCID 131725567, compound

HRID 1745235Notes

Reaction equation

HRID 1745235 reaction equation
[CH2:1]([O:4][N:5]=[C:6]1[CH2:10][N:9]([C:11]([O:13]C(C)(C)C)=O)[C@H:8]([C:18]([OH:20])=O)[CH2:7]1)[CH:2]=[CH2:3].[CH3:21][N:22]([CH3:29])[CH2:23][CH2:24][CH2:25]C(Cl)=O.[C:30]1([CH2:40][NH2:41])[C:39]2[C:34](=[CH:35][CH:36]=[CH:37][CH:38]=2)[CH:33]=[CH:32][CH:31]=1>>[CH2:1]([O:4][N:5]=[C:6]1[CH2:10][N:9]([C:11](=[O:13])[CH2:25][CH2:24][CH2:23][N:22]([CH3:29])[CH3:21])[C@H:8]([C:18]([NH:41][CH2:40][C:30]2[C:39]3[C:34](=[CH:35][CH:36]=[CH:37][CH:38]=3)[CH:33]=[CH:32][CH:31]=2)=[O:20])[CH2:7]1)[CH:2]=[CH2:3]

Participants

4

Reactant 3

HCID 83551-NaphthalenemethanamineHCID 150876904-(Dimethylamino)butanoyl chlorideHCID 58714562(2S,4EZ)-4-[(allyloxy)imino)-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid

Product 1

HCID 131725567HCID 131725567, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-4-[(allyloxy)imino]-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, 4-(dimethylamino)buta-noyl chloride, and 1-naphthylmethylamine the title compound was obtained in 85% purity by LC/MS. MS(ESI+): m/z=437.2.

Sources & evidence

ORD record
ord-f684da39a5ea4c83bdde4b6f02dfd766
Source dataset
uspto-grants-2006_03
Patent number
US07018988B2

Reaction notes

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