反应详情

2-Bromomethyl-thiazole-4-carbonitrile (1.6 g, 7.8 mmol) was dissolved in 20 mL DMF and sodium azide (0.768 g, 11.8 mmol) was added. The reaction was allowed to stir for 16 h at room temperature and then diluted with water (50 mL). The aqueous layer was extracted with ethyl acetate (3×) and the combined organic layers were washed again with 75 ml of brine, dried with anhydrous sodium sulfate and concentrated in vacuo to yield 1.20 g (92%) of the title compound as a gummy material which was used in next step with out further purification.

1. extractionThe aqueous layer was extracted with ethyl acetate (3×)
2. washthe combined organic layers were washed again with 75 ml of brine
3. dry with materialdried with anhydrous sodium sulfate
4. concentrationconcentrated in vacuo