Pyridine → HCID 22226281, compound

HRID 1745418Notes

Reaction equation

HRID 1745418 reaction equation
[Br:1]C[C:3]1([C:6]([C:8]2(CBr)[CH2:10][CH2:9]2)=[O:7])CC1.[N:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>C(O)C>[Br-:1].[CH:8]1([C:6]([CH2:3][N+:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[O:7])[CH2:9][CH2:10]1

Participants

4

Reactant 2

HCID 1049PyridineHCID 53675890HCID 53675890, compound

Product 1

HCID 22226281HCID 22226281, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2.4 g of 1-bromomethylcyclopropylketone and 5.8 cm3 of pyridine are introduced into a three-necked flask containing 40 cm3 of ethanol and then the mixture is heated for 2 hours under reflux. After concentrating to dryness at 40° C. under reduced pressure (2.7 kPa), the residue is taken up in twice 30 cm3 of diethyl. ether. After filtration, washing with diethyl ether, the precipitate is dried under reduced pressure (90 Pa) to give 3.4 g of 1-cyclopropylcarbonylmethylpyridinium bromide in the form of a cream-coloured solid melting at 160° C.

Workup

  1. temperaturethe mixture is heated for 2 hours
  2. temperatureunder reflux
  3. concentrationAfter concentrating to dryness at 40° C. under reduced pressure (2.7 kPa)
  4. filtrationAfter filtration
  5. washwashing with diethyl ether
  6. customthe precipitate is dried under reduced pressure (90 Pa)

Sources & evidence

ORD record
ord-711ededf458c4691a77b233758e28a62
Source dataset
uspto-grants-2006_03
Patent number
US07019110B2

Reaction notes

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