Pyridine → HCID 22226276, compound

HRID 1745420Notes

Reaction equation

HRID 1745420 reaction equation
Br.[Br:2][CH2:3][C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][N:7]=1)=[O:5].[N:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>O1CCCC1>[BrH:2].[O:5]=[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][N:7]=1)[CH2:3][N+:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Participants

4

Reactant 2

HCID 1049PyridineHCID 27762312-Bromo-1-(2-pyridinyl)-1-ethanone hydrobromide

Product 1

HCID 22226276HCID 22226276, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

5 g of 2-bromoacetylpyridine hydrobromide and 7 cm3 of pyridine are introduced into a three-necked flask containing 50 cm3 of tetrahydrofuran. The stirring is maintained for 2 days at room temperature and then the precipitate formed is filtered, washed with 30 cm3 of tetrahydrofuran and then dried at 40° C. under reduced pressure (90 Pa) to give 6.9 g of 1-[2-oxo-2-(2-pyridyl)ethyl]pyridinium hydrobromide in the form of a beige solid which is used as it is.

Workup

  1. customthe precipitate formed
  2. filtrationis filtered
  3. washwashed with 30 cm3 of tetrahydrofuran
  4. customdried at 40° C. under reduced pressure (90 Pa)

Sources & evidence

ORD record
ord-0c85520d45de457ab33b41002baeff00
Source dataset
uspto-grants-2006_03
Patent number
US07019110B2

Reaction notes

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