Tert-butyl (4'-fluoro-3-nitro-[1,1'-biphenyl]-4-YL)carbamate → Tert-butyl (3-amino-4'-fluoro-[1,1'-biphenyl]-4-YL)carbamate

HRID 1745517Notes

Reaction equation

HRID 1745517 reaction equation
[C:1]([O:5][C:6](=[O:24])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=2)=[CH:10][C:9]=1[N+:21]([O-])=O)([CH3:4])([CH3:3])[CH3:2]>[Ni]>[C:1]([O:5][C:6](=[O:24])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:15]=[CH:16][C:17]([F:20])=[CH:18][CH:19]=2)=[CH:10][C:9]=1[NH2:21])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 1

HCID 69592758Tert-butyl (4'-fluoro-3-nitro-[1,1'-biphenyl]-4-YL)carbamate

Product 1

HCID 59737201Tert-butyl (3-amino-4'-fluoro-[1,1'-biphenyl]-4-YL)carbamate

Reagents, catalysts & solvents 1

HCID 935NickelCatalyst

Procedure

Prepared from (4′-fluoro-3-nitro-biphenyl-4-yl)-carbamic acid tert.-butyl ester (Example B12) by catalytic hydrogenation with Raney-Nickel according to the general procedure G (method a). Obtained as a light yellow solid (3.40 g). MS (ISP) 303 [(M+H)+].

Sources & evidence

ORD record
ord-74ffff8d3ec14a96b81d38921a6604d8
Source dataset
uspto-grants-2006_03
Patent number
US07018998B2

Reaction notes

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