Triethylamine → HCID 69592810, compound

HRID 1745530Notes

Reaction equation

HRID 1745530 reaction equation
Cl.[N:2]1([C:7]2[CH:8]=[C:9]([CH:13]=[CH:14][N:15]=2)[C:10](Cl)=[O:11])[CH:6]=[CH:5][N:4]=[CH:3]1.[K+].[C:17]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])(=[O:22])[CH2:18]C([O-])=O.CCN(CC)CC.[Mg+2].[Cl-].[Cl-]>CC#N>[C:24]([O:23][C:17](=[O:22])[CH2:18][C:10]([C:9]1[CH:13]=[CH:14][N:15]=[C:7]([N:2]2[CH:6]=[CH:5][N:4]=[CH:3]2)[CH:8]=1)=[O:11])([CH3:27])([CH3:26])[CH3:25]

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 5360315Magnesium ChlorideHCID 22224958HCID 22224958, compoundHCID 23662309HCID 23662309, compound

Product 1

HCID 69592810HCID 69592810, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Prepared from 2-imidazol-1-yl-isonicotinoyl chloride hydrochloride [prepared by reaction of tert.-butyl 2-chloroisonicotinoate with imidazole and NaH in DMF at 80° C., treatment with formic acid at 50° C. and reaction with thionylchloride in toluene at 100° C.] and tert.-butyl malonate potassium salt with Et3N and MgCl2 in CH3CN according to general procedure H (method a). Obtained as a brown solid (10.8 g).

Sources & evidence

ORD record
ord-44b4073334da4998a1715b5cd6a14f30
Source dataset
uspto-grants-2006_03
Patent number
US07018998B2

Reaction notes

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