HCID 22224918, compound → HCID 69592857, compound

HRID 1745536Notes

Reaction equation

HRID 1745536 reaction equation
[N:1]1[N:2]=[CH:3][N:4]([C:6]2[CH:7]=[C:8]([CH:13]=[CH:14][CH:15]=2)[C:9]([O:11]C)=O)[CH:5]=1.[C:16]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])(=[O:18])[CH3:17].[Li]>>[C:20]([O:19][C:16](=[O:18])[CH2:17][C:9](=[O:11])[C:8]1[CH:13]=[CH:14][CH:15]=[C:6]([N:4]2[CH:5]=[N:1][N:2]=[CH:3]2)[CH:7]=1)([CH3:23])([CH3:22])[CH3:21]

Participants

3

Reactant 2

HCID 22224918HCID 22224918, compoundHCID 86586795Lithium Tert-butyl Acetate

Product 1

HCID 69592857HCID 69592857, compound

Procedure

Prepared from methyl 3-[1,2,4]triazol-4-yl-benzoate [prepared by reaction of 3-aminobenzoic acid with hydrazine hydrate and triethyl orthoformate in acetic acid at 120° C., followed by esterification with conc. H2SO4 in refluxing MeOH] by treatment with lithium tert.-butyl acetate according to general procedure H (method b). Obtained as a light yellow gum (870 mg).

Sources & evidence

ORD record
ord-dfda97f849964ff9bb82b4333df1271a
Source dataset
uspto-grants-2006_03
Patent number
US07018998B2

Reaction notes

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