Trifluoroacetic anhydride → 6-(2-Imidazol-1-yl-pyridin-4-yl)-2,2-dimethyl-[1,3]dioxin-4-one

HRID 1745560Notes

Reaction equation

HRID 1745560 reaction equation
[C:1]([O:5][C:6](=[O:21])[CH2:7][C:8]([C:10]1[CH:15]=[CH:14][N:13]=[C:12]([N:16]2[CH:20]=[CH:19][N:18]=[CH:17]2)[CH:11]=1)=[O:9])(C)([CH3:3])[CH3:2].C(OC(C(F)(F)F)=O)(C(F)(F)F)=O>C(O)(C(F)(F)F)=O.CC(C)=O>[N:16]1([C:12]2[CH:11]=[C:10]([C:8]3[O:9][C:1]([CH3:3])([CH3:2])[O:5][C:6](=[O:21])[CH:7]=3)[CH:15]=[CH:14][N:13]=2)[CH:20]=[CH:19][N:18]=[CH:17]1

Participants

4

Reactant 2

HCID 9845Trifluoroacetic anhydrideHCID 69592810HCID 69592810, compound

Product 1

HCID 222248626-(2-Imidazol-1-yl-pyridin-4-yl)-2,2-dimethyl-[1,3]dioxin-4-one

Reagents, catalysts & solvents 1

HCID 86586799TFA acetoneSolvent

Procedure

Prepared from 3-(2-imidazol-1-yl-pyridin-4-yl)-3-oxo-propionic acid tert.-butyl ester (Example H5) by stirring in TFA/acetone with TFAA according to general procedure J (method b). Obtained as a brown solid (10.8 g).

Sources & evidence

ORD record
ord-34464304468a42c290597a36b9425597
Source dataset
uspto-grants-2006_03
Patent number
US07018998B2

Reaction notes

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