Trifluoroacetic anhydride → 2,2-Dimethyl-6-[3-(2-methyl-imidazol-1-yl)-phenyl]-[1,3]dioxin-4-one

HRID 1745561Notes

Reaction equation

HRID 1745561 reaction equation
[C:1]([O:5][C:6](=[O:22])[CH2:7][C:8]([C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([N:16]2[CH:20]=[CH:19][N:18]=[C:17]2[CH3:21])[CH:11]=1)=[O:9])(C)([CH3:3])[CH3:2].C(OC(C(F)(F)F)=O)(C(F)(F)F)=O>C(O)(C(F)(F)F)=O.CC(C)=O>[CH3:2][C:1]1([CH3:3])[O:5][C:6](=[O:22])[CH:7]=[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([N:16]3[CH:20]=[CH:19][N:18]=[C:17]3[CH3:21])[CH:11]=2)[O:9]1

Participants

4

Reactant 2

HCID 9845Trifluoroacetic anhydrideHCID 695927863-[3-(2-Methyl-imidazol-1-yl)-phenyl]-3-oxo-propionic acid tert.-butyl ester

Product 1

HCID 222247902,2-Dimethyl-6-[3-(2-methyl-imidazol-1-yl)-phenyl]-[1,3]dioxin-4-one

Reagents, catalysts & solvents 1

HCID 86586799TFA acetoneSolvent

Procedure

Prepared from 3-[3-(2-methyl-imidazol-1-yl)-phenyl]-3-oxo-propionic acid tert.-butyl ester (Example H8) by stirring in TFA/acetone with TFAA according to general procedure J (method b). Obtained as a beige solid (2.13 g).

Sources & evidence

ORD record
ord-cb56e8d16bd3448a9f0ba04abda11c72
Source dataset
uspto-grants-2006_03
Patent number
US07018998B2

Reaction notes

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