Trifluoroacetic acid → 4-(3-Chloro-phenyl)-8-phenyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one

HRID 1745672Notes

Reaction equation

HRID 1745672 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:10][C:9]=1[NH2:20])(C)(C)C.[Cl:22][C:23]1[CH:24]=[C:25]([C:29]2OC(C)(C)O[C:31](=[O:37])[CH:30]=2)[CH:26]=[CH:27][CH:28]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[Cl:22][C:23]1[CH:24]=[C:25]([C:29]2[CH2:30][C:31](=[O:37])[NH:20][C:9]3[CH:10]=[C:11]([C:14]4[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=4)[CH:12]=[CH:13][C:8]=3[N:7]=2)[CH:26]=[CH:27][CH:28]=1

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 222246906-(3-Chloro-phenyl)-2,2-dimethyl-[1,3]dioxin-4-oneHCID 57717454N-(3-Amino[1,1'-biphenyl]-4-yl)-carbamic Acid tert-Butyl Ester

Product 1

HCID 222249324-(3-Chloro-phenyl)-8-phenyl-1,3-dihydro-benzo[b][1,4]diazepin-2-oneYield 54.2%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Prepared from (3-amino-biphenyl-4-yl)-carbamic acid tert.-butyl ester (Example G9) (284 mg, 1.0 mmol) and 6-(3-Chloro-phenyl)-2,2-dimethyl-[1,3]dioxin-4-one (Example J6) (358 mg, 1.2 mmol) according to the general procedure K. The obtained material (339 mg) was deprotected and cyclized by treatment with TFA in CH2Cl2 according to the general procedure M. Obtained as a yellow solid (188 mg).

Sources & evidence

ORD record
ord-9512b16d8e914aea9fe5b1ddef92fdfc
Source dataset
uspto-grants-2006_03
Patent number
US07018998B2

Reaction notes

Loading…