Trifluoroacetic acid → HCID 69592812, compound

HRID 1745699Notes

Reaction equation

HRID 1745699 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10](C2OC3=CC=CC3=CC=2)[C:9]=1[NH:23][C:24](=[O:36])[CH2:25][C:26]([C:28]1[CH:33]=[CH:32][CH:31]=[C:30]([C:34]#[N:35])[CH:29]=1)=O)(C)(C)C.[C:38]([OH:44])([C:40](F)(F)F)=O>C(Cl)Cl>[O:44]1[C:38]2[C:40]([CH:10]=[CH:11][CH:12]=2)=[CH:13][CH:8]=[C:9]1[CH:25]1[C:26]([C:28]2[CH:29]=[C:30]([CH:31]=[CH:32][CH:33]=2)[C:34]#[N:35])=[N:7][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[NH:23][C:24]1=[O:36]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86588083HCID 86588083, compound

Product 1

HCID 69592812HCID 69592812, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Prepared from {4-benzofuran-2-yl-2-[3-(3-cyano-phenyl)-3-oxo-propionylamino]-phenyl}-carbamic acid tert.-butyl ester (Example K28) (255 mg, 0.51 mmol) by treatment with TFA in CH2Cl2 according to the general procedure M. Obtained as a yellow solid (260 mg).

Sources & evidence

ORD record
ord-8f0f0e982151414e8d47e82b4b3893b8
Source dataset
uspto-grants-2006_03
Patent number
US07018998B2

Reaction notes

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