Trifluoroacetic acid → 4-[2-(3-Imidazol-1-yl-phenyl)-4-oxo-4,5-dihydro-3H-benzo[b][1,4]diazepin-7-yl]-benzonitrile

HRID 1745709Notes

Reaction equation

HRID 1745709 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][C:17]([C:20]#[N:21])=[CH:16][CH:15]=2)=[CH:10][C:9]=1[NH:22][C:23](=[O:38])[CH2:24][C:25]([C:27]1[CH:32]=[CH:31][CH:30]=[C:29]([N:33]2[CH:37]=[CH:36][N:35]=[CH:34]2)[CH:28]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[N:33]1([C:29]2[CH:28]=[C:27]([C:25]3[CH2:24][C:23](=[O:38])[NH:22][C:9]4[CH:10]=[C:11]([C:14]5[CH:15]=[CH:16][C:17]([C:20]#[N:21])=[CH:18][CH:19]=5)[CH:12]=[CH:13][C:8]=4[N:7]=3)[CH:32]=[CH:31][CH:30]=2)[CH:37]=[CH:36][N:35]=[CH:34]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86588027{4'-Cyano-3-[3-(3-imidazol-1-yl-phenyl)-3-oxo-propionylamino]-biphenyl-4-yl}-carbamic acid tert-butyl ester

Product 1

HCID 222247364-[2-(3-Imidazol-1-yl-phenyl)-4-oxo-4,5-dihydro-3H-benzo[b][1,4]diazepin-7-yl]-benzonitrile

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Prepared from {4′-cyano-3-[3-(3-imidazol-1-yl-phenyl)-3-oxo-propionylamino]-biphenyl-4-yl}-carbamic acid tert-butyl ester (Example K41) by treatment with TFA in CH2Cl2 according to the general procedure M. Obtained as a light yellow solid (128 mg).

Sources & evidence

ORD record
ord-8a5410e6961c41cb96b719bf617ddffa
Source dataset
uspto-grants-2006_03
Patent number
US07018998B2

Reaction notes

Loading…