Trifluoroacetic acid → HCID 22224670, compound

HRID 1745768Notes

Reaction equation

HRID 1745768 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[C:18]([F:20])[CH:17]=CC=2F)=[CH:10][C:9]=1[NH:22][C:23](=[O:38])[CH2:24][C:25](=O)[C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([N:32]2[CH:36]=[CH:35][N:34]=[N:33]2)[CH:27]=1)(C)(C)C.[C:40](O)([C:42]([F:45])(F)F)=O>C(Cl)Cl>[F:45][C:42]1[CH:40]=[CH:17][C:18]([F:20])=[CH:19][C:14]=1[C:11]1[CH:12]=[CH:13][C:8]2[N:7]=[C:25]([C:26]3[CH:31]=[CH:30][CH:29]=[C:28]([N:32]4[CH:36]=[CH:35][N:34]=[N:33]4)[CH:27]=3)[CH2:24][C:23](=[O:38])[NH:22][C:9]=2[CH:10]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86601095HCID 86601095, compound

Product 1

HCID 22224670HCID 22224670, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Prepared from {2′,5′-difluoro-3-[3-oxo-3-(3-[1,2,3]triazol-1-yl-phenyl)-propionylamino]-biphenyl-4-yl}-carbamic acid tert.-butyl ester (Example K93) by treatment with TFA in CH2Cl2 according to the general procedure M. Obtained as a light yellow solid (67 mg).

Sources & evidence

ORD record
ord-c9989f5b54ca41f1ad88461648330988
Source dataset
uspto-grants-2006_03
Patent number
US07018998B2

Reaction notes

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