HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 22224724, compound → HCID 22224797, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 22224724 | HCID 22224724 | — |
| Catalyst | Sodium Hydroxide | HCID 14798 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 22224797 | HCID 22224797 | 58.9% |
Reaction Steps
Prepared from 8-phenylethynyl-4-(3-trimethylsilanylethynyl-phenyl)-1,3-dihydro-benzo[b][1,4]diazepin-2-one (Example 132) (63 mg, 0.146 mmol) by treatment with 1N NaOH (3 drops) in MeOH (3 mL) and THF (0.5 mL) at 23° C. for 2 h. Obtained as a brown solid (31 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07018998B2 |
| Source dataset | uspto-grants-2006_03 |
| ORD ID | ord-b43169379e844a15a5c31ee9ebe9c70a |
| Source note | uspto-grants-2006_03 |