HCID 22224724, compound → HCID 22224797, compound

HRID 1745774Notes

Reaction equation

HRID 1745774 reaction equation
[C:1]1([C:7]#[C:8][C:9]2[CH:10]=[CH:11][C:12]3[N:18]=[C:17]([C:19]4[CH:24]=[CH:23][CH:22]=[C:21]([C:25]#[C:26][Si](C)(C)C)[CH:20]=4)[CH2:16][C:15](=[O:31])[NH:14][C:13]=3[CH:32]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>[OH-].[Na+].CO.C1COCC1>[C:25]([C:21]1[CH:20]=[C:19]([C:17]2[CH2:16][C:15](=[O:31])[NH:14][C:13]3[CH:32]=[C:9]([C:8]#[C:7][C:1]4[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=4)[CH:10]=[CH:11][C:12]=3[N:18]=2)[CH:24]=[CH:23][CH:22]=1)#[CH:26]

Participants

5

Reactant 1

HCID 22224724HCID 22224724, compound

Product 1

HCID 22224797HCID 22224797, compoundYield 58.9%

Reagents, catalysts & solvents 3

HCID 14798Sodium HydroxideCatalystHCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

Prepared from 8-phenylethynyl-4-(3-trimethylsilanylethynyl-phenyl)-1,3-dihydro-benzo[b][1,4]diazepin-2-one (Example 132) (63 mg, 0.146 mmol) by treatment with 1N NaOH (3 drops) in MeOH (3 mL) and THF (0.5 mL) at 23° C. for 2 h. Obtained as a brown solid (31 mg).

Sources & evidence

ORD record
ord-b43169379e844a15a5c31ee9ebe9c70a
Source dataset
uspto-grants-2006_03
Patent number
US07018998B2

Reaction notes

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