Iodo benzene diacetate → HCID 131725681, compound

Participants

Reaction Steps

With reference to EXAMPLE 1-2, 11 mg (0.034 mmol) of iodobenzene diacetate was added to a mixture of 10 mg (0.035 mmol) of 4-ferrocenylurazole and 0.5 mL of tetrahydrofuran at room temperature. The mixture was stirred for an hour to give the tetrahydrofuran solution of 4-ferrocenyl-1,2,4-triazoline-3,5-dione. A tetrahydrofuran (0.5 mL) solution of 10 mg (0.026 mmol) of cholecalciferol (VD3, manufactured by Solvay Pharmaceutical, Co.) was added to the solution obtained, followed by stirring at room temperature for an hour. The resulting mixture was concentrated under reduced pressure and the residue obtained was purified by thin layer silica gel chromatography (hexane:ethyl acetate=2:1) to give 11 mg (63%) of the titled cholecalciferol/4-ferrocenyl-1,2,4-triazoline-3,5-dione adduct (VD3-FTAD) as a yellow oily substance.

Provenance & Evidence