Iodo benzene diacetate → HCID 131725681, compound

HRID 1745848Notes

Reaction equation

HRID 1745848 reaction equation
C(O)(=O)C.C(O)(=O)C.I[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12]C=1.[C-:16]1([N:21]2[C:25](=[O:26])[NH:24][NH:23][C:22]2=[O:27])[CH:20]=[CH:19][CH:18]=[CH:17]1.[CH-]1C=CC=C1.[Fe+2:33]>O1CCCC1>[C-:16]1([N:21]2[C:22](=[O:27])[N:23]=[N:24][C:25]2=[O:26])[CH:17]=[CH:18][CH:19]=[CH:20]1.[CH-:12]1[CH:13]=[CH:14][CH:15]=[CH:10]1.[Fe+2:33]

Participants

4

Reactant 2

HCID 12217721Iodo benzene diacetateHCID 178518852HCID 178518852, compound

Product 1

HCID 131725681HCID 131725681, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

With reference to EXAMPLE 1-2, 11 mg (0.034 mmol) of iodobenzene diacetate was added to a mixture of 10 mg (0.035 mmol) of 4-ferrocenylurazole and 0.5 mL of tetrahydrofuran at room temperature. The mixture was stirred for an hour to give the tetrahydrofuran solution of 4-ferrocenyl-1,2,4-triazoline-3,5-dione. A tetrahydrofuran (0.5 mL) solution of 10 mg (0.026 mmol) of cholecalciferol (VD3, manufactured by Solvay Pharmaceutical, Co.) was added to the solution obtained, followed by stirring at room temperature for an hour. The resulting mixture was concentrated under reduced pressure and the residue obtained was purified by thin layer silica gel chromatography (hexane:ethyl acetate=2:1) to give 11 mg (63%) of the titled cholecalciferol/4-ferrocenyl-1,2,4-triazoline-3,5-dione adduct (VD3-FTAD) as a yellow oily substance.

Sources & evidence

ORD record
ord-8d0774022866453c856b7e0a02fe6bc7
Source dataset
uspto-grants-2006_03
Patent number
US07019146B1

Reaction notes

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