反应详情

To a cooled solution of tert-butyl(trans)-2-(3′-chlorobiphenyl-4-yl)cyclopropylcarbamate (3 g) in Et2O (15 mL) at 0° C. was added HCl in Et2O (15 mL), stirred for 16 h at RT. The progress of the reaction was monitored by TLC. After completion, the solvent was evaporated, residue was triturated with. Et2O to get (Trans)-2-(3′-chlorobiphenyl-4-yl)cyclopropanamine as HCl salt (2.3 g, 95.8%) as a white solid. The HCl salt was made free base by using NaHCO3 solution and used in next reaction.

1. customAfter completion, the solvent was evaporated
2. customresidue was triturated with