4-Chlorostyrene → 3-(Pyrimidin-5-yloxy)-4,5-dihydroisoxazole

HRID 1746130노트

반응식

HRID 1746130 반응식
ClC1C=CC(C=C)=CC=1.Br[C:11]1[CH2:15][CH2:14][O:13][N:12]=1.[OH:16][C:17]1[CH:18]=[N:19][CH:20]=[N:21][CH:22]=1>>[N:19]1[CH:18]=[C:17]([O:16][C:11]2[CH2:15][CH2:14][O:13][N:12]=2)[CH:22]=[N:21][CH:20]=1

참가 물질

4

반응물 3

HCID 140854-ChlorostyreneHCID 565855Pyrimidin-5-olHCID 219834983-Bromo-4,5-dihydroisoxazole

생성물 1

HCID 866505643-(Pyrimidin-5-yloxy)-4,5-dihydroisoxazole

실험 절차

3-(pyrimidin-5-yloxy)-4,5-dihydroisoxazole I-153a and I-153b were prepared in 2 steps 1-chloro-4-vinylbenzene using Method 1. The resulting bromo-4,5-dihydroisoxazole was reacted with 5-hydroxypyrimidine using Method 5. These compounds can be separated using chiral HPLC methods known in the art. For example, see chiral HPLC Method disclosed herein. [M+H]+=277.3 m/z. Activity: B

후처리

  1. customThese compounds can be separated

출처 및 근거

ORD 기록
ord-14a240d43ded45d185bb5448cfc38d51
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09149465B2

반응 노트

불러오는 중…