HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chlorostyrene → 3-(Pyrimidin-5-yloxy)-4,5-dihydroisoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chlorostyrene | HCID 14085 | — |
| Reactant | Pyrimidin-5-ol | HCID 565855 | — |
| Reactant | 3-Bromo-4,5-dihydroisoxazole | HCID 21983498 | — |
| Product | 3-(Pyrimidin-5-yloxy)-4,5-dihydroisoxazole | HCID 86650564 | — |
Reaction Steps
3-(pyrimidin-5-yloxy)-4,5-dihydroisoxazole I-153a and I-153b were prepared in 2 steps 1-chloro-4-vinylbenzene using Method 1. The resulting bromo-4,5-dihydroisoxazole was reacted with 5-hydroxypyrimidine using Method 5. These compounds can be separated using chiral HPLC methods known in the art. For example, see chiral HPLC Method disclosed herein. [M+H]+=277.3 m/z. Activity: B
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09149465B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-14a240d43ded45d185bb5448cfc38d51 |
| Source note | uspto-grants-2015_10 |