Cyclopropylboronic acid → HCID 178498917, compound

HRID 1746231Notes

Reaction equation

HRID 1746231 reaction equation
[CH3:1][O:2][C:3]([C:5]1[C:6](=[O:17])[S:7][C:8]2[C:13]([C:14]=1[OH:15])=[CH:12][CH:11]=[C:10](Br)[CH:9]=2)=[O:4].[CH:18]1(B(O)O)[CH2:20][CH2:19]1>>[CH3:1][O:2][C:3]([C:5]1[C:6](=[O:17])[S:7][C:8]2[C:13]([C:14]=1[OH:15])=[CH:12][CH:11]=[C:10]([CH:18]1[CH2:20][CH2:19]1)[CH:9]=2)=[O:4]

Participants

3

Reactant 2

HCID 2760897Cyclopropylboronic acidHCID 178498916HCID 178498916, compound

Product 1

HCID 178498917HCID 178498917, compound

Procedure

7-Cyclopropyl-4-hydroxy-2-oxo-2H-thiochromene-3-carboxylic acid methyl ester was prepared from 7-bromo-4-hydroxy-2-oxo-2H-thiochromene-3-carboxylic acid methyl ester under conditions analogous to Example 7(a) using cyclopropylboronic acid. The crude material was used in the next step without purification.

Workup

  1. customThe crude material was used in the next step without purification

Sources & evidence

ORD record
ord-f8aafeb5033346889a6e5670ea55cf38
Source dataset
uspto-grants-2015_10
Patent number
US09149476B2

Reaction notes

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