4-(4-Acetylphenyl)-1,2,4-triazolidine-3,5-dione → 4-(4-acetylphenyl)-3H-1,2,4-triazole-3,5(4H)-dione

HRID 1746261Notes

Reaction equation

HRID 1746261 reaction equation
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[C:14](=[O:15])[NH:13][NH:12][C:11]2=[O:16])=[CH:6][CH:5]=1)(=[O:3])[CH3:2]>C(Cl)Cl>[C:1]([C:4]1[CH:5]=[CH:6][C:7]([N:10]2[C:11](=[O:16])[N:12]=[N:13][C:14]2=[O:15])=[CH:8][CH:9]=1)(=[O:3])[CH3:2]

Participants

3

Reactant 1

HCID 533076914-(4-Acetylphenyl)-1,2,4-triazolidine-3,5-dione

Product 1

HCID 533076924-(4-acetylphenyl)-3H-1,2,4-triazole-3,5(4H)-dioneYield 74%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To 4-(4-acetylphenyl)-1,2,4-triazolidine-3,5-dione (115 mg, 0.999 mmol) in CH2Cl2 (3.5 mL) was added SiO2-HNO3 (300 mg). The mixture was stirred at room temperature for 15 minutes, filtered, concentrated in vacuo and dried to give 4-(4-acetylphenyl)-3H-1,2,4-triazole-3,5(4H)-dione as a red solid (78 mg, 74%).

Workup

  1. filtrationfiltered
  2. concentrationconcentrated in vacuo
  3. customdried

Sources & evidence

ORD record
ord-abf0cea78b6c42c4bf6e4b6a98c2db34
Source dataset
uspto-grants-2015_10
Patent number
US09149541B2

Reaction notes

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