HCID 86718996, compound → HCID 86718997, compound

HRID 1746280Notes

Reaction equation

HRID 1746280 reaction equation
[CH2:1]([O:4][CH:5]([CH2:14][O:15][CH2:16][C:17]#[CH:18])[CH2:6][N:7]1[C:11](=[O:12])[NH:10][NH:9][C:8]1=[O:13])[C:2]#[CH:3]>C(Cl)Cl>[CH2:1]([O:4][CH:5]([CH2:14][O:15][CH2:16][C:17]#[CH:18])[CH2:6][N:7]1[C:8](=[O:13])[N:9]=[N:10][C:11]1=[O:12])[C:2]#[CH:3]

Participants

3

Reactant 1

HCID 86718996HCID 86718996, compound

Product 1

HCID 86718997HCID 86718997, compoundYield 100.8%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To 4-(2,3-bis(prop-2-ynyloxy)propyl)-1,2,4-triazolidine-3,5-dione (I-13d: 50 mg, 0.199 mmol) in CH2Cl2 (1.99 mL) was added SiO2-HNO3 (150 mg). The mixture was stirred at room temperature for 15 minutes, then filtered, concentrated in vacuo and dried giving 4-(2,3-bis(prop-2-ynyloxy)propyl)-3H-1,2,4-triazole-3,5(4H)-dione (I-13e: 50 mg, quantitative) as a red oil.

Workup

  1. filtrationfiltered
  2. concentrationconcentrated in vacuo
  3. customdried

Sources & evidence

ORD record
ord-bb52b39a75bd421eb45755e351a6a74e
Source dataset
uspto-grants-2015_10
Patent number
US09149541B2

Reaction notes

Loading…