Hydrochloric Acid → HCID 86682255, compound

HRID 1746376Notes

Reaction equation

HRID 1746376 reaction equation
[NH2:1][C@H:2]([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[CH:14][CH:13]=1)[CH2:3][C@:4]([CH2:9][OH:10])([CH3:8])[C:5]([OH:7])=[O:6].[CH3:24][CH2:25]O.Cl>O1CCOCC1>[CH2:24]([O:6][C:5](=[O:7])[C@@:4]([CH2:9][OH:10])([CH3:8])[CH2:3][C@H:2]([NH2:1])[CH2:11][C:12]1[CH:13]=[CH:14][C:15]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[CH:16][CH:17]=1)[CH3:25]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 68181056(2S,4R)-4-Amino-5-biphenyl-4-yl-2-hydroxymethyl-2-methylpentanoic acid

Product 1

HCID 86682255HCID 86682255, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

(2S,4R)-4-Amino-5-biphenyl-4-yl-2-hydroxymethyl-2-methylpentanoic acid (0.3 g, 957 μmol) was combined with EtOH (6 mL) and 4 M of HCl in 1,4-dioxane (718 μL), and stirred overnight. The solvents were evaporated and the product was azeotroped with toluene (2×) to yield the title compound (295 mg), which was used without further purification.

Workup

  1. customThe solvents were evaporated
  2. customthe product was azeotroped with toluene (2×)

Sources & evidence

ORD record
ord-b64d2b51bd9c4c028cd660833af86be0
Source dataset
uspto-grants-2015_10
Patent number
US09150500B2

Reaction notes

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