Ethanol hydrochloride → Hydrochloric Acid

HRID 1746377Notes

Reaction equation

HRID 1746377 reaction equation
[CH3:1][O:2][C:3](=[O:24])[C@H:4]([OH:23])[CH2:5][N:6]([CH2:15][C:16]1[CH:21]=[CH:20][C:19]([Br:22])=[CH:18][CH:17]=1)[NH:7]C(OC(C)(C)C)=O.[CH3:25]CO.[ClH:28]>>[CH2:1]([O:2][C:3](=[O:24])[CH:4]([OH:23])[CH2:5][N:6]([CH2:15][C:16]1[CH:21]=[CH:20][C:19]([Br:22])=[CH:18][CH:17]=1)[NH2:7])[CH3:25].[ClH:28]

Participants

4

Reactant 2

HCID 21887872Ethanol hydrochlorideHCID 67972599HCID 67972599, compound

Product 2

HCID 313Hydrochloric AcidYield 663.5%HCID 866822563-[N-(4-Bromobenzyl)hydrazino]-2-hydroxypropionic Acid Ethyl Ester

Procedure

A solution of (R)-3-[N-(4-bromobenzyl)-N′-t-butoxycarbonylhydrazino]-2-hydroxypropionic acid methyl ester (25 g, 62 mmol) in EtOH/HCl (310 mL, 1.0 M, 0.3 mol) was stirred overnight. The mixture was concentrated and the reside was washed with EtOAc (120 mL) and filtered to yield the title compound as a white solid HCl salt (15 g).

Workup

  1. concentrationThe mixture was concentrated
  2. washthe reside was washed with EtOAc (120 mL)
  3. filtrationfiltered

Sources & evidence

ORD record
ord-4294ecdc753940b593b8086a07148c86
Source dataset
uspto-grants-2015_10
Patent number
US09150500B2

Reaction notes

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