Hydrochloric Acid → HCID 178497975, compound

HRID 1746448Notes

Reaction equation

HRID 1746448 reaction equation
[OH:1][C:2]1[N:7]=[C:6]([C:8]([OH:10])=[O:9])[CH:5]=[CH:4][CH:3]=1.Cl.[CH3:12]O>O1CCOCC1>[OH:1][C:2]1[N:7]=[C:6]([C:8]([O:10][CH3:12])=[O:9])[CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 178524392HCID 178524392, compound

Product 1

HCID 178497975HCID 178497975, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a solution of 6-hydroxypicolinic acid (13.0 g, 93.5 mmol) in methanol (150 mL) at room temperature was added HCl in dioxane (4N, 10 mL). The resulting mixture was stirred at room temperature for 48 hours. The reaction mixture was concentrated to give methyl 6-hydroxypicolinate (13 g, 90%) as a white solid.

Workup

  1. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-0ea8309935b64a5b993a372cfbc00d2d
Source dataset
uspto-grants-2015_10
Patent number
US09150526B2

Reaction notes

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