反应详情

温度

-10 °C

To a solution of 4-(methylsulfonyl)phenol (5 g, 29.1 mmol) in ether (100 mL) at −15° C. was slowly added acetic acid (5 mL). To this cold solution was slowly added Br2 (5.1 g, 32.0 mmol) and the reaction was stirred at −10° C. for 1 h and then warmed to r.t. and stirred for further 10 h. After the reaction was completed, 100 mL of sat. NaHCO3 aq. was added and the mixture was extracted with EA (50 mL×3). The combined organic layers were washed with brine and dried over Na2SO4. After filtration and evaporation of the solvent, 2-bromo-4-(methylsulfonyl)phenol (3.2 g, 43.6%) was obtained as a white solid.

1. customat −15° C.
2. temperaturewarmed to r.t.
3. stirringstirred for further 10 h
4. extractionthe mixture was extracted with EA (50 mL×3)
5. washThe combined organic layers were washed with brine
6. dry with materialdried over Na2SO4
7. filtrationAfter filtration and evaporation of the solvent