Sodium Hydroxide → Sodium Nalpha-[3-(2,6-Difluorophenyl)acryloyl]-L-Tryptophanate

HRID 1746540Notes

Reaction equation

HRID 1746540 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[CH:9]=[CH:10][C:11]([NH:13][C@H:14]([C:25]([O:27]C)=[O:26])[CH2:15][C:16]1[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[NH:18][CH:17]=1)=[O:12].[OH-].[Na+:30]>CO>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[CH:9]=[CH:10][C:11]([NH:13][C@H:14]([C:25]([O-:27])=[O:26])[CH2:15][C:16]1[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[NH:18][CH:17]=1)=[O:12].[Na+:30]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86655446Methyl Nalpha-[3-(2,6-Difluorophenyl)acryloyl]-L-Tryptophanate

Product 1

HCID 86655492Sodium Nalpha-[3-(2,6-Difluorophenyl)acryloyl]-L-TryptophanateYield 68%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The same procedures as in Example 60 were carried out from the compound obtained in Example 13 (3.9 g), 1 mol/L of an aqueous sodium hydroxide solution (15 mL), and methanol (150 mL), to give the captioned compound (2.7 g, 68%) as an amorphous solid product.

Sources & evidence

ORD record
ord-cce4a6d800b7490e9be972fd4d5ed303
Source dataset
uspto-grants-2015_10
Patent number
US09150510B2

Reaction notes

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