1,4-Dioxane hydrochloride → HCID 67130504, compound

HRID 1746580Notes

Reaction equation

HRID 1746580 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]=[CH:9][C:10]([NH:12][C@H:13]([C:26]([OH:28])=[O:27])[CH2:14][CH2:15][CH2:16][CH2:17][NH:18]C(OC(C)(C)C)=O)=[O:11].[ClH:29].O1CCOCC1>C(Cl)Cl>[ClH:29].[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]=[CH:9][C:10]([NH:12][C@H:13]([C:26]([OH:28])=[O:27])[CH2:14][CH2:15][CH2:16][CH2:17][NH2:18])=[O:11]

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 86655521HCID 86655521, compound

Product 1

HCID 67130504HCID 67130504, compoundYield 92%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The same procedures as in Example 29 were carried out from the compound obtained in Example 113 (3.8 g), 4 mol/L of hydrogen chloride-dioxane (7.0 mL), and methylene chloride (80 mL), to give the captioned compound (3.0 g, 92%) as crystals.

Sources & evidence

ORD record
ord-67c8fe6f8c04434e8b4dcac635544676
Source dataset
uspto-grants-2015_10
Patent number
US09150510B2

Reaction notes

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