Trifluoroacetic acid → HCID 178512854, compound

HRID 1746582Notes

Reaction equation

HRID 1746582 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]=[CH:9][C:10]([NH:12][C@H:13]([C:38]([OH:40])=[O:39])[CH2:14][CH2:15][CH2:16][NH:17][C:18](=[NH:37])[NH:19]S(C1C(C)C2CC(C)(C)OC2=C(C)C=1C)(=O)=O)=[O:11].FC(F)(F)C(O)=O>C(Cl)Cl>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]=[CH:9][C:10]([NH:12][C@H:13]([C:38]([OH:40])=[O:39])[CH2:14][CH2:15][CH2:16][NH:17][C:18](=[NH:19])[NH2:37])=[O:11]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178421682HCID 178421682, compound

Product 1

HCID 178512854HCID 178512854, compoundYield 89.5%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To methylene chloride solution of the compound obtained in Example 115 (2.8 g) was added dropwise trifluoroacetic acid (50 mL) at room temperature, and the mixture was allowed to stir for 24 hours. To the residue obtained by distilling off the solvent under a reduced pressure was added diethylether, and the mixture was stirred for 24 hours at room temperature. The crystals precipitated were filtered, to give the captioned compound (1.4 g, 68%).

Workup

  1. customTo the residue obtained
  2. distillationby distilling off the solvent under a reduced pressure
  3. additionwas added diethylether
  4. stirringthe mixture was stirred for 24 hours at room temperature
  5. customThe crystals precipitated
  6. filtrationwere filtered

Sources & evidence

ORD record
ord-95ddf7c03fba4edaa77bf766296533a0
Source dataset
uspto-grants-2015_10
Patent number
US09150510B2

Reaction notes

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