HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Hydroxysuccinimide → HCID 86655524, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Hydroxysuccinimide | HCID 80170 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 3-(3-Cyanophenyl)-2-propenoic acid | HCID 44725869 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 86655524 | HCID 86655524 | 93% |
Reaction Steps
To methylene chloride (300 mL) suspension of 3-cyanocinnamic acid (9.0 g) and N-hydroxysuccinic acid imide (9.0 g) was added WSC.HCl (15.0 g) at 0° C., and the mixture was stirred for 6 hours at room temperature. The reaction mixture was washed with water, and the organic layer was dried over anhydrous sodium sulfate. The crystals obtained by distilling off the solvent under a reduced pressure were filtered with diethyl ether, to give the captioned compound (13.0 g, 93%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09150510B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-6d0c7a0dd4f5499a9c92d5011c848595 |
| Source note | uspto-grants-2015_10 |