反应详情

To methylene chloride (300 mL) suspension of 3-cyanocinnamic acid (9.0 g) and N-hydroxysuccinic acid imide (9.0 g) was added WSC.HCl (15.0 g) at 0° C., and the mixture was stirred for 6 hours at room temperature. The reaction mixture was washed with water, and the organic layer was dried over anhydrous sodium sulfate. The crystals obtained by distilling off the solvent under a reduced pressure were filtered with diethyl ether, to give the captioned compound (13.0 g, 93%).

1. washThe reaction mixture was washed with water
2. dry with materialthe organic layer was dried over anhydrous sodium sulfate
3. customThe crystals obtained
4. distillationby distilling off the solvent under a reduced pressure
5. filtrationwere filtered with diethyl ether