N-Hydroxysuccinimide → HCID 86655525, compound

HRID 1746584Notes

Reaction equation

HRID 1746584 reaction equation
[C:1]([C:3]1[CH:13]=[CH:12][C:6]([CH:7]=[CH:8][C:9]([OH:11])=[O:10])=[CH:5][CH:4]=1)#[N:2].O[N:15]1[C:19](=[O:20])[CH2:18][CH2:17][C:16]1=[O:21].CCN=C=NCCCN(C)C.Cl>C(Cl)Cl>[C:1]([C:3]1[CH:13]=[CH:12][C:6]([CH:7]=[CH:8][C:9]([O:11][N:15]2[C:19](=[O:20])[CH2:18][CH2:17][C:16]2=[O:21])=[O:10])=[CH:5][CH:4]=1)#[N:2]

Participants

5

Reactant 3

HCID 80170N-HydroxysuccinimideHCID 86773p-Cyanocinnamic acidHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride

Product 1

HCID 86655525HCID 86655525, compoundYield 79.5%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The same procedures as in Example 117 were carried out from 4-cyanocinnamic acid (5.0 g), N-hydroxysuccinic acid imide (5.0 g), WSC.HCl (8.3 g), and methylene chloride (150 mL), to give the captioned compound (6.2 g, 79%) as crystals.

Sources & evidence

ORD record
ord-3c11f9890b3d449db584af9a1e2c37ca
Source dataset
uspto-grants-2015_10
Patent number
US09150510B2

Reaction notes

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