N-Hydroxysuccinimide → HCID 86655526, compound

HRID 1746585Notes

Reaction equation

HRID 1746585 reaction equation
[C:1]([C:3](=[CH:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[F:14])[C:4]([OH:6])=[O:5])#[N:2].O[N:16]1[C:20](=[O:21])[CH2:19][CH2:18][C:17]1=[O:22].CCN=C=NCCCN(C)C.Cl>C(Cl)Cl>[C:1]([C:3](=[CH:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[F:14])[C:4]([O:6][N:16]1[C:20](=[O:21])[CH2:19][CH2:18][C:17]1=[O:22])=[O:5])#[N:2]

Participants

5

Reactant 3

HCID 80170N-HydroxysuccinimideHCID 367937HCID 367937, compoundHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride

Product 1

HCID 86655526HCID 86655526, compoundYield 44.2%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The same procedures as in Example 119 were carried out from α-cyano-2-fluorocinnamic acid (12.0 g), N-hydroxysuccinic acid imide (10.8 g), WSC.HCl (18.1 g), and methylene chloride (300 mL), to give the captioned compound (8.0 g, 44%) as crystals.

Sources & evidence

ORD record
ord-2ad8a245bd6949488d3d61fd2e8255f5
Source dataset
uspto-grants-2015_10
Patent number
US09150510B2

Reaction notes

Loading…