1,4-Dioxane hydrochloride → HCID 67130572, compound

HRID 1746599Notes

Reaction equation

HRID 1746599 reaction equation
C(OC([NH:8][C@H:9]([C:24]([O:26][CH3:27])=[O:25])[CH2:10][C:11]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[N:13]([CH2:20][CH2:21][CH2:22][CH3:23])[CH:12]=1)=O)(C)(C)C.[ClH:28].O1CCOCC1>C(Cl)Cl>[ClH:28].[CH2:20]([N:13]1[C:14]2[C:19](=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:11]([CH2:10][C@@H:9]([C:24]([O:26][CH3:27])=[O:25])[NH2:8])=[CH:12]1)[CH2:21][CH2:22][CH3:23]

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 67130680HCID 67130680, compound

Product 1

HCID 67130572HCID 67130572, compoundYield 63%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The same procedures as in Example 143 were carried out from the compound obtained in Example 142 (4.2 g), 4 mol/L of hydrogen chloride-dioxane solution (14.0 mL), and methylene chloride (140 mL), to give the captioned compound (2.2 g, 63%) as crystals.

Sources & evidence

ORD record
ord-e59708f322d846f18fe9e1820cf7413c
Source dataset
uspto-grants-2015_10
Patent number
US09150510B2

Reaction notes

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