1,4-Dioxane hydrochloride → HCID 67130661, compound

HRID 1746607Notes

Reaction equation

HRID 1746607 reaction equation
[CH2:1]([N:8]1[C:36]2[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=2)[C:10]([CH2:11][C@@H:12]([C:21]([O:23][CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)=[O:22])[NH:13]C(OC(C)(C)C)=O)=[CH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:37].O1CCOCC1>C(Cl)Cl>[ClH:37].[CH2:1]([N:8]1[C:36]2[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=2)[C:10]([CH2:11][C@@H:12]([C:21]([O:23][CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)=[O:22])[NH2:13])=[CH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 67130653HCID 67130653, compound

Product 1

HCID 67130661HCID 67130661, compoundYield 81%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The same procedures as in Example 143 were carried out from the compound obtained in Example 152 (12.2 g), 4 mol/L of hydrogen chloride-dioxane solution (31 mL), and methylene chloride (300 mL), to give the captioned compound (8.6 g, 81%) as crystals.

Sources & evidence

ORD record
ord-17a1adef001449c0a138837312b4a487
Source dataset
uspto-grants-2015_10
Patent number
US09150510B2

Reaction notes

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