4-Aminoquinoline → 6-(cyclohexylamino)-N-quinolin-4-ylpyrimidine-4-carboxamide

HRID 1746701Notes

Reaction equation

HRID 1746701 reaction equation
[CH:1]1([NH:7][C:8]2[N:13]=[CH:12][N:11]=[C:10]([C:14]([OH:16])=O)[CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:17][C:18]1[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[N:21]=[CH:20][CH:19]=1>CO>[CH:1]1([NH:7][C:8]2[N:13]=[CH:12][N:11]=[C:10]([C:14]([NH:17][C:18]3[C:27]4[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=4)[N:21]=[CH:20][CH:19]=3)=[O:16])[CH:9]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

4

Reactant 2

HCID 684764-AminoquinolineHCID 594470756-(Cyclohexylamino)pyrimidine-4-carboxylic acid2×

Product 1

HCID 251827546-(cyclohexylamino)-N-quinolin-4-ylpyrimidine-4-carboxamide

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Following the general method as outlined in Example 1, starting from 6-(cyclohexylamino)pyrimidine-4-carboxylic acid (Intermediate 4) and 4-aminoquinoline (Tyger), the title compound was obtained as a red solid after trituration in methanol.

Sources & evidence

ORD record
ord-217ccfb93fd646198155f8c06d0e1be1
Source dataset
uspto-grants-2015_10
Patent number
US09150519B2

Reaction notes

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