2-Methylcyclohexylamine → HCID 25182762, compound

HRID 1746709Notes

Reaction equation

HRID 1746709 reaction equation
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([C:8]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][C:12]=2[CH3:18])=[O:9])[CH:3]=1.[CH3:19][CH:20]1[CH2:25][CH2:24][CH2:23][CH2:22][CH:21]1[NH2:26]>>[OH:17][C:14]1[CH:15]=[CH:16][C:11]([NH:10][C:8]([C:4]2[CH:3]=[C:2]([NH:26][CH:21]3[CH2:22][CH2:23][CH2:24][CH2:25][CH:20]3[CH3:19])[N:7]=[CH:6][N:5]=2)=[O:9])=[C:12]([CH3:18])[CH:13]=1

Participants

3

Reactant 2

HCID 234322-MethylcyclohexylamineHCID 594471056-chloro-N-(4-hydroxy-2-methylphenyl)pyrimidine-4-carboxamide2×

Product 1

HCID 25182762HCID 25182762, compound

Procedure

Following the general method as outlined in Example 20, starting from 6-chloro-N-(4-hydroxy-2-methylphenyl)pyrimidine-4-carboxamide (Intermediate 8) and 2-methylcyclohexylamine (Aldrich), the title compound was obtained as a white solid after purification by column chromatography (silica) eluting with cyclohexane containing increasing amounts of EtOAc.

Sources & evidence

ORD record
ord-22d5af31953e435cb3dbc572f1d1644d
Source dataset
uspto-grants-2015_10
Patent number
US09150519B2

Reaction notes

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