4-Amino-3-methylbenzene-1-sulfonamide → N-[4-(aminosulfonyl)-2-methylphenyl]-6-(cyclohexyloxy)pyrimidine-4-carboxamide
Reaction equation
[CH:1]1([O:7][C:8]2[N:13]=[CH:12][N:11]=[C:10]([C:14]([OH:16])=O)[CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:17][C:18]1[CH:23]=[CH:22][C:21]([S:24]([NH2:27])(=[O:26])=[O:25])=[CH:20][C:19]=1[CH3:28]>>[NH2:27][S:24]([C:21]1[CH:22]=[CH:23][C:18]([NH:17][C:14]([C:10]2[CH:9]=[C:8]([O:7][CH:1]3[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]3)[N:13]=[CH:12][N:11]=2)=[O:16])=[C:19]([CH3:28])[CH:20]=1)(=[O:25])=[O:26]Participants
3
Procedure
Following the general method as outlined in Example 1, starting 6-(cyclohexyloxy)pyrimidine-4-carboxylic acid (Intermediate 32) and 4-amino-3-methylbenzenesulfonamide (Biofine), the title compound was obtained as a white solid.
Sources & evidence
- ORD record
- ord-3aaac8420bb94a6baafd610f17c218c5
- Source dataset
- uspto-grants-2015_10
- Patent number
- US09150519B2
Reaction notes
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