Bis(2-Methoxyethyl)amine → 6-[bis(2-methoxyethyl)amino]-N-1H-indazol-5-ylpyrimidine-4-carboxamide

HRID 1746747Notes

Reaction equation

HRID 1746747 reaction equation
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([C:8]([NH:10][C:11]2[CH:12]=[C:13]3[C:17](=[CH:18][CH:19]=2)[NH:16][N:15]=[CH:14]3)=[O:9])[CH:3]=1.[CH3:20][O:21][CH2:22][CH2:23][NH:24][CH2:25][CH2:26][O:27][CH3:28]>>[CH3:20][O:21][CH2:22][CH2:23][N:24]([CH2:25][CH2:26][O:27][CH3:28])[C:2]1[N:7]=[CH:6][N:5]=[C:4]([C:8]([NH:10][C:11]2[CH:12]=[C:13]3[C:17](=[CH:18][CH:19]=2)[NH:16][N:15]=[CH:14]3)=[O:9])[CH:3]=1

Participants

3

Reactant 2

HCID 2383Bis(2-Methoxyethyl)amineHCID 594468806-chloro-N-1H-indazol-5-ylpyrimidine-4-carboxamide2×

Product 1

HCID 251829146-[bis(2-methoxyethyl)amino]-N-1H-indazol-5-ylpyrimidine-4-carboxamide

Procedure

Following the general method as outlined in Example 20, starting from 6-chloro-pyrimidine-4-carboxylic acid (1H-indazol-5-yl)-amide (Intermediate 16) and bis(2-methoxyethyl)amine (Aldrich), the title compound was obtained as a white solid.

Sources & evidence

ORD record
ord-1bf54df0cfc14235a8ae31264b024f66
Source dataset
uspto-grants-2015_10
Patent number
US09150519B2

Reaction notes

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