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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1746753Generated: November 1, 2026

tert-Butyl piperazine-1-carboxylate → HCID 59446822, compound

https://huagongshe.com/reaction/1746753

Reaction equation

Participants

RoleNameHCIDCharge
Reactanttert-Butyl piperazine-1-carboxylateHCID 143452—
Reactant6-[cyclohexyl(cyclopropylmethyl)amino]-N-(4-formylphenyl)pyrimidine-4-carboxamideHCID 59446846—
ProductHCID 59446822HCID 59446822—

Reaction Steps

Following the general method as outlined in Example 73, starting from 6-[cyclohexyl(cyclopropylmethyl)amino]-N-(4-formylphenyl)pyrimidine-4-carboxamide (Intermediate 24) and 1-boc-piperazine (Fluka), the title compound was obtained as a white solid after purification by column chromatography (silica) eluting with cyclohexane containing increasing amounts of EtOAc.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09150519B2
Source datasetuspto-grants-2015_10
ORD IDord-fa9953abeb80442580edacfb6becfc48
Source noteuspto-grants-2015_10