反应详情

The compound 13 (220 mg) was dissolved in methanol (1.1 mL), a p-toluenesulfonic acid monohydrate (20 mg) was added at room temperature, and the mixture was stirred for 2 hours. The residue obtained by concentration of the reaction liquid under reduced pressure was purified by silica gel column chromatography (hexane:ethyl acetate=2:1→1:1→ethyl acetate) to obtain a titled compound (82 mg) having the following physical property values.

1. customThe residue obtained by concentration of the reaction liquid under reduced pressure
2. customwas purified by silica gel column chromatography (hexane:ethyl acetate=2:1→1:1→ethyl acetate)