Hydrochloric Acid → HCID 89644270, compound

Participants

Reaction Steps

To 1.09 g (1.45 mmol) of (R)-2-((S)-3-tert-Butoxycarbonylamino-2-oxo-pyrrolidin-1-yl)-3-[7-trifluoromethoxy-1-(trityl-amino)-isoquinolin-6-yl]-propionic acid methyl ester, dissolved in 6 ml abs. CH2Cl2, 1.7 ml (6 eq) etheric HCl-solution are added at 0° C. The reaction mixture is stirred for 3 h at this temperature. After warming up to r.t., the solid product is isolated by filtration: 588 mg are obtained.

Provenance & Evidence